A note about the index: The pages referenced in this index refer to the page numbers in the print edition. Clicking on a page number will take you to the ebook location that corresponds to the beginning of that page in the print edition. For a comprehensive list of locations of any word or phrase, use your reading system’s search function.
AAA Foundation, 138
Accreditation Council for Graduate Medical Education, 320
Adderall, 315
addiction, and sleep disturbance, 149
adenosine
caffeine’s impact on, 27–28
circadian rhythm alignment with, 31–33
naps and amount of, 99
overnight release of, during sleep, 33
sleep deprivation and, 34–35, 36
sleep pressure and, 27, 29–30, 31–32, 35, 291
sleep urge and, 32–33
wakefulness and accumulation of, 27, 34
ADHD. See attention deficit hyperactivity disorder
adolescents, 87–95
circadian rhythm changes and sleep time in, 92–95
deep-sleep intensity and brain maturation in, 87–91
early school start times and, 92
impact of childhood REM-sleep deprivation on, 82
memory benefit of NREM sleep in, 115
REM sleep re-tuning benefit for, 217
schizophrenia and abnormal brain development in, 92
sleep amount needed by, 94
sleep disruption and suicidal thoughts in, 148
transition from dependence to independence in, 94–95
aging. See also older adults
learning capacity and sleep spindles affected by, 111
sleep quality deterioration and, 157
alarm clocks, 280–81
alcohol use
childhood sleep loss as predictor of later, 149
performance and, 138
REM sleep blocking by, 82–85, 272, 274
sleep hygiene and reducing use of, 291
sleep rhythm affected by, 265, 271–75
Alzheimer’s disease, 157–63
insomnia in, 158
sleep disruption and onset of, 103, 157–58, 159, 161–62, 163
sleep improvements as treatment for, 162–63
Ambien (zolpidem), 282, 284, 285, 287, 288, 289
American Academy of Pediatrics, 314
American College of Physicians, 292
American Medical Association, 246
amygdala, 146–47, 195, 208, 210, 245
amyloid, Alzheimer’s disease, 102, 158–61
anagram-solving task, and dreaming, 223–25, 226
animal species
memory benefit of sleep in, 115–16
sleep research in, 6, 56–57, 58, 60, 71
aquatic mammals, sleep in, 60–61, 62, 64
Ariely, Dan, 281
Aristotle, 199–200
athletes
importance of sleep for, 128–31
post-performance sleep and, 130
practice and sleep in, 124–28
sleep loss and injuries in, 129
attention deficit hyperactivity disorder (ADHD)
abnormal brain development in, 91
sleep deficiency and, 149, 314–16
auditory stimulation
for memory retention, 119–20
for sleep, 117–18
autism spectrum disorder (ASD)
maternal alcohol use and, 83
REM-sleep abnormalities in, 74, 81–82
awake periods. See also wakefulness
alcohol-infused sleep with, 271–72
memory retention in, 113
polyphasic sleep pattern in children alternating with, 85–86
bacteria, active-passive phases in, 57
Barns, Christopher, 301, 302–3
bats, sleep in, 57, 58, 59, 60
Begin, Menachem, 306–7
Belenky, Gregory, 137
Belsomra (suvorexant), 254
Berry, Wendell, 281
Bertolini, Mark, 333
beta-amyloid, in Alzheimer’s disease, 102, 158–61
biological clock. See also circadian rhythm
factors in resetting of, 17–18
jet lag and, 24–27
suprachiasmatic nucleus control of, 18–19, 20, 22, 25, 31, 39, 86, 267
biphasic sleep pattern
biological nature of, 69–70
first sleep and second sleep and, 70
health impact of changing from, 71
hunter-gatherer peoples and, 68
night sleep and nap in, 69–71
siesta cultures with, 70–71
bipolar disorder
abnormal brain development in, 91
normal sleep as remedy for, 151
sleep disruption in, 149, 150–51
birds
sleep in, 44, 56, 60, 61, 62, 63, 65, 66
transoceanic migration and sleep deprivation in, 67–68
blindness, circadian rhythm in, 18
blood pressure
adequate sleep for lowering, 8, 329
sleep deprivation and, 165–66, 168, 280
sleep disruption from medications for, 340
body position during, 38–39
body temperature
circadian rhythm and, 19–20
physical activity before bedtime and, 294
skin and cooling of, 276
sleep initiation and, 19, 98, 245, 256, 275
sleep deprivation with drop in, 258
Bolt, Usain, 128
Boux, St. Paul, 222
brain
adolescent sleep and maturation of, 87–91
aging and deterioration in, 101–2
autism and synaptic connections in, 81
benefits of sleep for, 108
childhood sleep and neural connections in, 80–81, 87–88
dreams and activity in, 194–99
evolutionary changes and development of, 58–59
eye movement patterns in sleep and, 42
fetal sleep and neural connections in, 78, 79–81, 87
infant sleep deprivation and, 80–81
jet lag impact on, 27
memory functions in, 109
memory locations in, 114–15
NREM and REM sleep cycle domination of, 43
REM sleep involvement of, 66, 82, 207–8
resetting of biological clock and, 17–18
schizophrenia and development of, 92
sensory blackout in, during sleep, 39–40
sleep benefit for, 7
sleep cycles and neural connections in, 44–45
sleep disruption in mental disorders and, 149–50
sleep generation and, 46–55
sleeping pills and, 282
sleep pressure and adenosine in, 27
sleep rebound and, 63–64
split-brain approach to NREM sleep, 65
unihemispheric sleep in half of, 64–66
brain stimulation technologies, 103, 116–18
brainwaves
charting patterns of, 46–47
dreaming and, 194–99
lifespan sleep pattern changes in, 87
muscle activity during, 53–54
NREM sleep and, 48–52
REM sleep and, 52–55
rocking stimulation and, 118
schizophrenia and, 92
site of origin of, 49–50
sleep generation and, 46–48
sleeping pills and, 282–83
sleep spindles during, 49
sleep stimulation technologies using, 103, 116–18
thalamus’s sensory blackout and, 50–51, 53
wakefulness and, 47–48
breastfeeding, and maternal alcohol use, 84–85
addictive aspect of, 30
adenosine blockage by, 27–28, 29–30
child and adolescent use of, 30, 95
crash from overuse of, 29
foods containing, 28–29
genetic factors affecting sensitivity to, 29
healthy sleep by avoiding, 340
persistence in system of, 28
sleep deficiency and need for, 35, 36
sleep deprivation remedy using, 144, 145
sleep hygiene and reducing use of, 291
sleep inertia and, 143
sleeping pill usage and, 283
spider web building affected by, 30
cancer
metastatic spread of, 185–86
sleep disruption and, 157, 183–86
sleeping pill use and, 289
car crashes
drowsiness after sleep deprivation and, 4, 134, 138–43, 319
sleeping pill use and, 288
cardiovascular health
sleep deprivation and, 129, 165–69
sleep patterns and, 71
Cartwright, Rosalind, 210–11
Centers for Disease Control and Prevention, 261, 314
cerebrum
NREM slow-wave sleep in, 50–51
REM sleep and development of, 80–81
switching between NREM and REM sleep cycle domination of, 43
unihemispheric sleep in, 64
cetaceans, sleep in, 60–61, 64
child obstructive sleep apnea, 315
children
adolescent impact of REM-sleep deprivation in, 82
behavioral impact of sleep deprivation in, 148, 149
cataplexy in, 250–51
circadian rhythm in, 86–87, 93
maternal alcohol use and blocking of REM sleep in, 82–85
memory benefit of NREM sleep in, 115
neural connection development during sleep in, 80–81, 87–88, 91
NREM and REM sleep percentages in, 87
obesity and sleep loss in, 177–78
polyphasic sleep pattern in, 85–86
REM sleep re-tuning benefit for, 217
sleeping pills and, 285
chimpanzees, sleep in, 72, 76, 115
chronotype
genetics and, 21
morning larks versus night owls in, 21–22
work schedules and, 21–22, 304, 334
cingulate cortex, and dreaming, 195
circadian rhythm, 13–20
adenosine alignment with, 31–33
adolescent sleep times and, 92–95
autistic children and, 81
body temperature and, 19–20
cancer and disruption of, 184
children and development of, 86–87, 93
daylight resetting of, 17–18
description of, 13–14
early school start times and, 92
evening types (“night owls”) and, 20–22
evolutionary precursor of, 57
identifying someone sleeping and, 39
individual differences in, 20–22
jet lag and, 24–27
length of sleep-wake cycle in, 16–17
lighting changes and, 326–28
Mammoth Cave experiment on, 15–17
morning types (“morning larks”) and, 20–22
older adults and, 98–101
plant heliotropism similar to, 14–15
preferences and functions controlled by, 14
reasons for variability in, 22
sleep deprivation and, 34–35
sleep pressure and, 31–32
sleep trackers and, 325–26
sleep urge and, 32–33
suprachiasmatic nucleus control of, 18–19
wakefulness urge and, 32
work schedules and, 21–22, 304
coffee
de-caffeinated versus non-caffeinated, 29
healthy sleep by avoiding, 340
sleep inertia and, 143
cognitive behavioral therapy for insomnia (CBT-I), 151, 290–92, 334
cognitive function
adolescent sleep and development of, 90
deep NREM sleep and refinement of, 90
dreaming state of REM sleep and, 195
elderly sleep problems and, 91, 102–3, 162
insomnia affecting, 246
sleep deprivation and, 138, 140, 145, 254, 315
colds, and sleep loss, 182
concentration
caffeine to stay awake and, 29
low testosterone and, 179
naps for preserving, 144–45
sleep deprivation and, 134–37, 138
consolidation of memories
brain amyloid deposits in older adults and, 160, 162
naps and amount of, 115
sleep needed for, 112–14, 156–57
Corke, Michael, 254–55
coronary artery blockage, 3, 166
coronary heart disease, 3, 165, 166
cortex
alcohol use immobilization of, 271
dreaming in REM sleep and, 195, 203, 208
early morning functioning of, 20–21
impact of sleep loss on emotional control in, 147–48, 149, 176, 195, 210
memory storage in, 110–11, 114–15
REM brainwave activity in, 61–62
sleep and sensory processing in, 40, 51, 196
sleeping pill use and, 246, 282, 284
corticosterone, 259
creativity
dreaming and, 75–76, 207, 219–22
napping and, 232
sleep loss among employees and, 299
Crick, Francis, 5, 120–21, 122
Dallenbach, Karl, 112–13
Darwin, Charles, 15
daylight
circadian rhythm independent of, 15–17
circadian rhythm resetting by, 17–18, 100
jet lag and biological clock resetting using, 25
melatonin release blocked by, 23–24, 100
plant heliotropism and, 14–15
daylight savings time, 169
deep slow-wave sleep, 48, 49, 51
de Mairan, Jean-Jacques d’Ortous, 14–15
de Manacéïne, Marie, 259–60
Dement, William, 42
electrical brain signature forecasting, 9
electrical brainwave activity in, 9
sleep disruption related to, 157
sleep disturbances mistaken for, 98
types of, 9
depression
abnormal brain development in, 91
dream content in, 211
normal sleep as remedy for, 151
sleep deprivation as therapy for, 151–52
sleep disturbance in, 103, 149, 314
sleep quality improvements for, 151
diabetes, 169–71
blood sugar levels in, 169–70, 171
chronic sleep loss and, 21, 26, 103, 133, 164, 170–71, 243, 330
diet
Dijk, Derk-Jan, 187–88
Dinges, David, 134–36, 137, 143–44, 145
dinosaurs, sleep in, 57
doctors, and hospital work schedules, 316–22, 335
dolphins, sleep in, 60–61, 62, 64, 66
dreams, 191–234
anagram-solving task and, 223–25, 226
autobiographical content of, 203–4, 231
brainwave activity during, 194–99
creativity benefit of, 75–76, 207, 219–22, 232
decoding waking experiences in, 214–18
emotional and mental health and, 207–14
emotional themes and concerns in, 204–5
epiphenomenal nature of, 206, 207
evolutionary changes and, 61, 62, 66, 75–76, 77
fetal sleep and, 79
Freud’s theory of, 194, 196, 200–201, 203
functional benefits of, 205, 206–7
generic interpretations of, 201–3
lucidity in, 232–34
memory association network task and, 225–26
memory melding in, 226–28
muscle activity and movement-rich experience of, 54
overnight therapy theory of, 207–11, 214
predicting content of, 196–99
problem-solving abilities and, 207, 224–25, 228–29, 230–31
psychoanalytic interpretation of, 200–3, 204–5
REM sleep functions and, 206–07
stages of sleep with, 193–94
theories on sources of, 198–201
time sense during, 40–41
tree versus ground sleeping and, 74
virtual maze task and, 230–31
childhood sleep loss as predictor of, 149
doctors and, 317–18
drunk drivers
performance of, 138
duck-billed platypus, sleep in, 61–62
Edina, Minnesota, school system, 311–12
Edison, Thomas, 231–32, 265, 266
education
Edina, Minnesota, changes in, 311–12
school start times and, 92, 311–12
sleep change suggestions for, 331–33
elderly. See older adults
electric light
controlling for better sleep, 270, 326–28
sleep rhythm affected by, 265–70
Ellenbogen, Jeffrey, 227
emotional content of dreams, 204–5
emotional IQ, 74
emotional irrationality, and sleep deprivation, 146–52
emotional issues
cataplexy and, 250
employment schedules. See work schedules
eszopiclone (Lunesta), 282, 288
Eternal Sunshine of the Spotless Mind (movie), 122–23
evening types (“night owls”), 20–22
circadian rhythm variations and, 20–21
genetics and, 21
sleep deprivation and, 21
work schedules and, 21–22, 304, 334
evolution, 56–77
adolescent transition to independence and, 94–95
beginning of sleep seen in, 56, 57–58
brain development and sleep needs in, 58–59
circadian rhythm precursor and, 57
composition of sleep and, 60–64
creativity and, 76
half-brain versus whole-brain form of sleep and, 65–66, 71
lucid dreaming and, 234
NREM sleep and, 62–63
post-prandial alertness dip and, 69
REM sleep advantages of, 73–77
shift from sleeping in trees to ground sleeping and, 72–77
sleep pattern differences across various species and, 66–71
split-shift of sleep and, 70
tree versus ground sleeping and, 72–75
way of sleeping and, 64–66
eye movement patterns during sleep. See also rapid eye movement (REM) sleep
early research and discovery of, 42
fall risks, in older adults, 98
family
insomnia in, 254–57
sleepwalking in, 239–40
fast frequency brain activity, 47, 51
fatal familial insomnia (FFI), 254–57
causes of, 255–56
example of, 254–55
treatment of, 256–57
Feinberg, Irwin, 89–91
fetal sleep, 78–85
fight-or-flight response, 146–47, 167, 168, 176–77, 244–45, 280
fire, and ground sleeping, 73
first sleep and second sleep, 70
flu vaccine, sleep loss and response to, 182–83
follicular-releasing hormone, 180
Food and Drug Administration (FDA), 23, 214, 254, 289
forgetting
benefits of, 120
memory capacity limits and, 109
memory retention in awake periods and, 113
sleep for selective forgetting of memories, 120–23, 208–9
fracture risks, in older adults, 98, 104
Frankenstein (Shelley), 222
Freud, Sigmund, 5, 194, 196, 200–201, 203, 204
Freudian dream interpretation, 200–203, 204–5
frontal lobes
adolescent development of, 90, 91
alcohol use immobilization of, 271
Alzheimer’s amyloid accumulation in, 102, 158–61
deep-sleep brainwave generation in, 49, 159
memory processing and, 122
rational thinking and decision-making based in, 90–91, 271, 301
schizophrenia and synaptic pruning in, 92
sleep deprivation’s impact on, 301
Gabra people, Kenya, 68, 276–77
Garfunkel, Art, 115–16
genes, sleep loss impact on, 186–89
genetics
biphasic sleep pattern and, 69–70, 71
caffeine sensitivity and, 29
circadian rhythm and, 21
fatal familial insomnia and, 255, 256
insomnia and, 243
narcolepsy and, 247
shorter sleep amount needs and, 145
Gibson, Matthew, 303
glymphatic system, 160–61
Gozal, David, 185–86
Greece, siesta culture in, 70–71
growth hormone, 168
Halsted, William Stewart, 317–18, 321
Harvard Medical School, 9, 125, 156, 204, 223
Harvard University School of Public Health, 71
Harvey, Allison, 151
health
acclimation to effects of sleep loss on, 137
benefits of a full night of sleep for, 107–8
change from biphasic to monophasic sleep pattern and, 71
night owls and impact on, 21
sleep as foundation of, 164
sleep loss consequences for, 3–4
heart attack, 21, 133, 165, 166, 168, 169, 264, 307
heart disease, 71, 164, 165, 166, 170, 288
heliotropism, 14–15
hepatitis A and B vaccines, 183
hippocampus
amyloid in Alzheimer’s disease and, 159
dreaming and, 195
insomnia and, 245
REM sleep and processing in, 203–4, 208
short-term memory storage in, 114–15, 122
sleep deprivation and, 154, 155
textbook-type learning and, 109, 110–11
hospitals
neonatal intensive care treatment in, 337–38
pain treatment and sleep in, 335–37
work schedules in, 316–22, 335
humans
evolutionary advantages of REM sleep for, 73–77
tree versus ground sleeping and, 72–75
unihemispheric sleep in, 65–66
hunter-gatherer peoples
firelight and social activities of, 266
sleep amounts among, 260–63
sleep patterns among, 68, 69, 70, 267
temperature fluctuations during sleep of, 277
hypertension, 165–66, 168, 170
ideasthesia, 219–20
Iguodala, Andre, 130
sleep benefit for, 7
sleep deprivation and, 181–86, 258–59
incandescent lighting, 266, 268–69
infants
abstracting grammatical rules by, 228
beginning of circadian rhythm in, 86–87
discovery of REM sleep in, 42
impact of REM sleep deprivation in, 80–81
importance of REM sleep in, 85
maternal alcohol consumption and REM sleep in, 82–85
memory benefit of NREM sleep in, 115
number of sleep phases in, 85–86
nursing and sleep interruptions during, 84–85
sleep patterns in autism in, 81–82
transition from crawling to walking and NREM sleep spikes in, 131
influenza, 182–83
insects, sleep in, 56, 60, 115
insomnia, 240–46
Alzheimer’s disease and, 158
definition of, 240–41
diagnosis of, 241–42
duration of episodes in, 242
early-evening naps in older adults and, 99
fatal familial (FFI), 254–57
incidence and rates of, 242–43
physical factors in, 244–45
rebound, with sleeping pills, 283, 292
regular wake times and, 280
treatment of, 246, 284–85, 286, 334
triggers for, 243–44
types of, 241
Institute of Medicine, 321
interference forgetting, 109
International Olympic Committee, 128
Interpretation of Dreams, The (Freud), 200–01, 203
invertebrates, sleep in, 57
iPads, 326
melatonin release and use of, 269–70
Irwin, Michael, 184
Jagust, William, 158
Jenkins, John, 112–13
jet lag, 24–27
eastward versus westward direction of flying and, 25–26
example of, 24–25
impact on brain of, 26
melatonin and, 26–27
sunlight signals to counteract, 25
time zone changes and, 24
Kamitani, Yukiyasu, 197–98
killer whales, sleep in, 60, 67, 80n
Kleitman, Nathaniel, 15–17, 42, 55
Kripke, Daniel, 286–87, 288, 289
learning
aging and, 111
all-nighters among students and, 153–54, 155
brain memory storage shifts and, 109–11, 114
motor skill memory and, 123–31
practice and, 124–28
school start times and, 311–12
sleep deprivation’s blocking of, 154–55
sleep spindles and replenishment of ability for, 110
sleep-the-night-after, 112–20, 156–57
sleep-the-night-before, 109–12
time-of-night effect in, 127–28
LED lighting and devices, 265, 268–71, 325, 326–27
lethargus, 56
lifespan sleep patterns, 78–104
during adolescence, 87–95
before birth, 78–85
childhood, 85–87
in midlife and old age, 95–104
lighting
controlling for better sleep, 270, 326–28
sleep rhythm affected by, 265–70
work spaces and, 304
lucid dreaming, 232–34
Lunesta (eszopiclone), 282, 284, 288
mammals, 56–57
early developmental life in, 80–81
narcolepsy in, 247
REM sleep in, 60–62, 63, 74, 75, 80
sleep amount needed by, 58
sleep cycles in, 44
temperature range needed by, 258
Mansbach, Adam, 85–86
McCartney, Paul, 221
melatonin, 22–24
artificial light blocking, 267, 268
autistic children’s profile for, 81
blue LED light blocking, 269–70, 326, 327
concentrations in over-the-counter brands, 23
daylight’s impact on release of, 23–24, 100, 267, 275, 277
generation of sleep and, 23
jet lag and, 26–27
older adults’ use of, 100
regulated environmental light for, 328
as sleeping aid, 23
timing of sleep onset and, 22–23
work schedules and release of, 304
memories
REM sleep and replaying of, 41
sleep cycles and updating of, 44–46
sleep deprivation’s blocking of, 154–55
sleep for selective remembering and forgetting of, 120–23
memory
alcohol-infused sleep affecting, 273–74
amyloid plaques and decline of, 159
brain storage shifts and, 109–11, 114–15
creativity and, 132
motor skill learning and, 123–31
NREM sleep and, 113–14, 115, 116–17, 118, 119–20, 122
older adults’ sleep disturbances and loss of, 102
sleep benefits for, 108–9, 115–16
sleep consolidation of, 112–14, 115, 156–57
sleeping pills and, 284–85
targeted reactivation of, 116, 119–20
time-of-night effect with, 127–28
memory association network, 225–26
Mendeleev, Dmitri, 220–21, 226, 230
mental disorders, and sleep disruption, 149–50
microsleep, 134, 135–36, 140–41, 144, 169, 319
midlife, sleep in, 95–104
migration of birds, and sleep deprivation in, 67–68
monkeys, sleep in, 72
monophasic sleep pattern
children’s transition to, 86
health impact of changing to, 71
in modern adults, 68
timing of, with light availability, 68–69
in winter months, 68
morning types (“morning larks”), 20–22
circadian rhythm variations and, 20–21
work schedules and, 21–22, 304, 334
motor disorders, recovery from, 123–24
motor skill memory, 123–31
athletes and performance and, 128–31
motor skill memory and, 128–31
practice and sleep and, 124–28
stroke recovery and relearning of, 125, 131
time-of-night effect with, 127–28
muscle activity, in REM sleep, 53–54
nap pods, 304
naps
biphasic sleep pattern of continuous night sleep with, 69–71
creativity in dreaming during, 232
drowsiness after sleep deprivation and, 142–43
hunter-gatherer sleep patterns and, 68
memory consolidation during, 115
memory removal during, 123
motor skill improvement using, 128
older adults’ sleep problems related to, 99
post-prandial alertness dip after, 69
siesta cultures and, 70–71
sleep deprivation and, 143–46
work settings for, 304
narcolepsy, 246–54
core symptoms in, 247–51
definition of, 247
neurological basis of, 251–53
treatment of, 253–54
National Basketball Association (NBA), 130
National Institutes of Health, 293
National Sleep Foundation, 3n, 237, 261, 292, 296, 316
natural killer cells, 184
Nedergaard, Maiken, 160–61
neocortex, memory storage in, 114
neonates. See also infants
importance of REM sleep in, 85
intensive care unit design and sleep amounts in, 337–38
nervous system, and sleep amount needs, 58–59
night owls
circadian rhythm variations and, 20–21
sleep deprivation and, 21
work schedules and, 21–22, 304, 334
non-rapid eye movement (NREM) sleep
adolescent brain maturation related to, 88, 89–91
brain benefits of, 108
cardiovascular system benefits of, 168
children and, 87
creativity benefit of, 75–76, 224
diet and, 295
early research and discovery of, 42
evolutionary changes and, 60, 62–63
exercise and, 293
fetal, and maternal alcohol use, 84
fetal sleep similar to, 79
glymphatic system cleansing during, 160–61
impact of loss of significant amount of, 46
infant’s transition from crawling to walking and, 131
insomnia during, 246
memory benefit of, 113–14, 115, 116–17, 118, 119–20, 122
memory removal during, 123
mental and physical benefits of, 51–52
midlife and older age amount of, 96
motor skill learning and, 127, 131
muscle activity during, 53
neural connection updating during, 45
reflection of signals during, 53
rocking stimulation of, 118
schizophrenia and reduction in amount of, 92
sleep cycle patterns involving REM sleep and, 43–46
sleep deprivation in, 258
sleep rebound after loss of, 63–64
sleep stimulation technologies during, 116–17
split-brain, 65
stages of, 42–43
targeted memory reactivation during, 119–20
unihemispheric, 64–66
noradrenaline, 208, 212, 213–14, 245
obesity. See also weight gain
factors in, 177
sleep apnea and, 141
sleep loss and, 133, 164, 169, 175, 177–78, 243
older adults, 95–104
amount of sleep needed by, 95–96, 103–4
circadian rhythm changes in, 98–101
electrical brainwave activity in, 9
fragmentation of sleep in, 97–98, 101
impact of sleep disruption in, 97–98
key changes in sleep in, 96
learning capacity and sleep spindles experienced by, 111
medical problems related to sleep problems in, 96–97
melatonin for, 100
memory benefit of sleep in, 111, 115
myth of less sleep needed by, 95, 103
nighttime bathroom visits and risk of falls and fractures in, 97, 98, 100
sleep quality changes in, 96–97, 101–4, 111
over-the-counter sleep remedies
melatonin concentrations in, 23
size of industry, 243
sleep patterns and, 341
paradoxical insomnia, 241
paradoxical sleep, 52
parasitic memories, 120–21
Parks, Kenneth, 239–40
pediatric sleep-disordered breathing, 315
performance
athletes and, 128–31
motor skill memory in, 128–31
practice and sleep and, 124–28
recovery sleep and, 138
self-assessment of impairment and, 137
sleep deprivation and, 135–37
time-of-night effect with, 127–28
Physicians for Human Rights, 306
pilots, and power naps, 143–45
pineal gland, and melatonin, 22, 23, 267
pinnipeds, sleep in, 61
plants, circadian rhythm of, 14–15
platypus, sleep in, 61–62
polysomnography (PSG), 41–42
post-traumatic stress disorder (PTSD), 211–14
flashbacks in, 212
prazosin treatment and REM sleep in, 213–14
repetitive nightmares in, 212–13, 214
sleep disturbance in, 149, 212
post-prandial alertness dip, 69
power naps, 143–45
Prather, Aric, 182
prazosin, 213–14
prescription of sleep, 4
problem-solving abilities, and dreaming, 207, 224–25, 228–29, 230–31
Process-C and Process-S
sleep deprivation and, 34
sleep pressure and, 31–32
sleep urge and, 32–33
wakefulness urge and, 32
Project for a Scientific Psychology (Freud), 203
psychiatric conditions
sleep disruption related to, 3, 91, 92, 133, 149–50, 309
sleep quality improvements for, 116, 151
psychological issues, and insomnia, 244
rapid eye movement (REM) sleep
alcohol use and blocking of, 82–85, 272, 274
aquatic mammals with, 60–61
autism and abnormalities of, 74, 81–82
brain benefits of, 108
brain changes during, 207–8
brain connectivity development and, 82
brain hemispheric involvement in, 66
cataplexy and, 250
children and, 87
dreaming during. See dreams
early research and discovery of, 42
emotional IQ and, 74
evolutionary advantages of, 73–77
evolutionary changes and, 60–62, 66
eye movement during dreaming during, 55, 233
fetal sleep similar to, 78, 79
human differences from other species in, 72
impact of loss of significant amount of, 46
importance of, for neonatal and infant development, 85
integration of signals during, 53
memory removal during, 120–23
memory retention and, 113, 117
midlife amount of, 96
muscle activity during, 53–54, 250
problem-solving abilities and, 224–25
re-tuning benefit of, 216–17
sleep cycles in NREM sleep and, 43–46
sleep deprivation in, 257–58
sleep paralysis during, 233, 248–49, 253
sleep rebound after loss of, 63–64
socioemotional benefits of, 74–76, 217
thalamus’s sensory blackout during, 53
tree versus ground sleeping and, 72–73, 74–75
Raskind, Murray, 213–14
rational thinking
adolescent sleep and development of, 90–91
dreaming state of REM sleep and, 195
schizophrenia with abnormal pattern of brain maturation and, 92
sleep and regulation of, 74, 147, 210, 309
sleep disturbance and, 148, 149, 152
rats
brain maturation and sleep deprivation in, 91, 155
fetal development and REM sleep in, 80–81, 82
health degradation from sleep deprivation in, 258–59, 262, 337
lack of sleep and death in, 257–58
memory benefit of NREM sleep in, 115
memory replaying during REM sleep in, 41
sleeping pills and cancer rates in, 289
temperature and sleep in, 278
reactivation of memories, 116, 119–20
Reagan, Ronald, 162
recovery sleep, 63, 135, 138, 140, 183
reproductive system, 178–81
reptiles, sleep in, 56, 60, 62
Restoril (temazepam), 287, 288, 289
Richards, Keith, 221–22
Richardson, Bruce, 16–17
Ritalin, 315
rocking stimulation, and NREM sleep, 118
room temperature
ideal temperature for sleeping, 277
sleep rhythm affected by, 243, 265, 275–79
Rosekind, Mark, 143–44
Roth, Thomas, 145
San people, Namibia, 68, 260, 266, 277
SATED sleep health questionnaire, 37
“Satisfaction” (Richards), 221–22
schizophrenia
abnormal brain development in, 91–92
sleep disturbance in, 149, 309
Scholastic Assessment Test (SAT), 311–12
second sleep, 70
sedative hypnotics, 282
self-assessments
of our own sleep, 39–41
SATED sleep health questionnaire for, 37
semantic knowledge, 225–26
Shakespeare, William, 108
Shelley, Mary, 222
Shrader, Jeffrey, 303
siesta cultures, 70–71
Simon, Paul, 115–16
skill memory, 123–31
athletes and performance and, 128–31
practice and sleep and, 124–28
time-of-night effect with, 127–28
sleep
benefits of a full night of, 107–8
as prescription, 4
self-assessment of our own sleep, 39–41
stereotypical position during, 38–39
ways of identifying individuals who are sleeping, 38–39
sleep amount, 35–37
adolescent circadian rhythm changes and, 92–95
Alzheimer’s disease related to, 162
amount of sleep needed, 260–63
appetite related to, 172–73
autistic children and, 81–82
calorie consumption related to, 173–75
children and, 87
electric light affecting, 265–70
evolution and differences across species for, 58–60
factors affecting, 58, 59–60, 265
fetal development and, 78–79
gene with need for lesser amount of, 145
humans and, 72
hunter-gatherer peoples and, 68, 260–63
learning restoration related to, 112
mortality risk and, 263–64
older adults’ need for, 95–96, 103–4
performance loss related to lesser sleep amounts, 136–37
room temperature and, 265, 275–79
SATED questionnaire on, 37
simple assessment of, 35–36
sleep quality versus, 59
sleep rebound and, 63–64
time sense of, 40–41
work schedules and, 265, 279–81
sleep apnea, 36, 141, 162, 179, 315
sleep deficiency
impact of, 36
signs indicating, 36
simple assessment of, 35–36
sleep disorders and, 36
sleeping pills to remedy, 36–37
sleep deprivation, 133–89
acclimation to effects of, 137
all-nighters among students and, 33, 152–54, 155
Alzheimer’s disease onset related to, 103, 157–58, 159, 161–62, 163
brain impact of, 134–63
cancer and, 183–86
car crashes from drowsiness after, 4, 134, 138–43, 319
cardiovascular system and, 165–69
childhood, and later development, 82
cognitive impairment after, 138, 140, 145, 254, 315
concentration and, 134–37, 138
daylight savings time and, 169
death from, 257–60
diabetes from, 169–71
economic cost of, 298
emotional decoding and, 216–17
emotional impact of, 146–52
fetal, and impact on development, 80
forgetfulness and, 152–57
genes impacted by, 186–89
hospital work schedules and, 316–22
immune system and, 181–86
joint, between mother killer whales and calves, 67
memory consolidation and, 156–57
microsleeps after, 135–36
minimum amount of lost sleep for impairment in, 140
mortality risk and, 263–64
naps to remedy, 143–46
night owls and, 21
physical appearance changes from, 180–81
physical impact on health from, 21, 164–89
quality of sleep after, 57
recovery sleep after, 63 135, 138, 140, 183
reproductive system and, 178–81
school performance and, 308–16
self-assessment of amount of impairment after, 137–38, 140
sleep rebound after, 56n, 63–64, 103, 272
small number of people resilient to, 145
therapeutic use of, 151–52
torture using, 305–8
weight gain and obesity from, 171–78
work schedules and, 297–305
sleep disorders, 237–64. See also specific disorders
sleep deficiency from, 36
sleep disruption
impact on older adults of, 101–4
brain stimulation technologies to remedy, 103, 117–18
sleep generation
brain and, 46–55
melatonin and, 23
older adults’ ability in, 104
sleep hygiene
diet and, 295
exercise and, 293–94
general good sleep practices in, 292–95
individual transformation for, 325–26
suggestions for, 291
tips for, 340–41
brainwave activity and, 282–83
caffeine consumption and, 283
cancer and, 289
elderly adults’ use of, 96, 288
insomnia treatment using, 246
memory impact of, 285
mortality risk of, 286–88
perceived benefits of, 284–85
physical effects of using, 286–90
rebound insomnia and, 283, 292
sleep deficiency remedy using, 36–37
sleep intervention, 324
sleep loss. See sleep deprivation
sleep maintenance insomnia, 241
sleep medications, 282–85. See also sleeping pills
insomnia and, 243
narcolepsy and, 253–54
size of industry, 243
sleep onset, and melatonin, 22–23
sleep onset insomnia, 241
sleep paralysis, 233, 247, 248–49, 253
sleep patterns
differences across various species for, 66–71
environmental pressures or challenges affecting, 66–67
genetic aspects of, 69–70
human differences from other species in, 71–77
joint, between mother killer whales and calves, 67
monophasic and biphasic patterns, 68–71
polyphasic pattern, 85–86
transoceanic migration and, 67–68
tree versus ground sleeping and, 72–75
sleep pressure, 13
adenosine and, 27–28, 29–30, 31–32, 35, 291
caffeine and, 27–30
circadian rhythm and, 31–32
early-evening snoozes in older adults and later lack of, 99
sleep problems, in older adults, 96–97, 101–4, 111
sleep procrastination, 265
sleep rebound, 56n, 63–64, 103, 272
sleep rhythm
adenosine–circadian rhythm alignment and, 31–33
alcohol use and, 265–75
circadian rhythm and, 13–20
electric light affecting, 265–70
iPad usage and, 269–70
room temperature and, 265, 275–79
two main factors affecting, 13
work schedules and, 265, 279–81
brainwaves during, 49
daytime naps and, 128
functions of, 49
memories and, 127
memory refreshment and, 110–12
practice and time-of-night effect with, 127–28
rocking stimulation and, 118
selective remembering and forgetting of memories and, 122
sleep-state misperception, 241
sleep stimulation technologies, 103, 116–18
sleep time. See sleep amount
sleep trackers, 130, 325–26, 333
sleepwalking, 238–40
social loafing, 301–2
socioemotional world, REM benefits for, 74–76, 217
somnambulism, 238–40
diagnosis of, 238–39
example of, 239–40
treatment of, 240
Sonata (zaleplon), 288
“Sound of Silence, The” (Simon and Garfunkel), 115–16
sound stimulation
for memory retention, 119–20
for sleep, 117–18
spider web building, caffeine’s impact on, 30
split-brain deep NREM sleep, 65
sports. See athletes
Steinbeck, John, 230
Stickgold, Robert, 125, 156–57, 203–5, 223, 225, 230–31
stimulation technologies for sleep, 103, 116–18
striatum, and sleep deprivation, 148
stroke
movement recovery after, 125, 131
sleeping pills and risk of, 288
sleep loss and, 3, 21, 103, 133, 165, 168, 307
suicidal thoughts
normal sleep as remedy for, 151
sleep deprivation and, 3, 133, 148, 307, 309, 314
Sundelin, Tina, 180–81
sunlight. See daylight
suprachiasmatic nucleus
adolescent changes in, 93
behaviors controlled by, 19
body temperature controlled by, 20
circadian rhythm controlled by, 18–19, 25, 31, 39, 86, 93, 267
melatonin and, 22
suvorexant (Belsomra), 254, 284–85
sympathetic nervous system, 167–68, 185, 244, 245
targeted memory reactivation, 116, 119–20
teenagers. See adolescents
telomeres, sleep loss and damage to, 188–89
temazepam (Restoril), 287, 288, 289
temperature. See body temperature; room temperature
Terman, Lewis, 310–11
thalamus
sensory signals during sleep and, 39–40, 50–51, 53, 251
sleep-wake switch and, 251, 252
Thatcher, Margaret, 162
time-of-night effect, in learning, 127–28
time sense, and amount of sleep, 40–41
time spent in sleep. See sleep amount
torture, sleep deprivation in, 305–8
truck drivers, and drowsy-driving crashes, 141–42
type 2 diabetes, 26, 169, 170–71
unicellular organisms, active-passive phases in, 57
unihemispheric sleep
in animals, 64–65
in humans, 65–66
US Department of Defense, 307–8
US Federal Aviation Authority (FAA), 143, 144
US Food and Drug Administration (FDA), 23, 214, 254, 285, 289
US National Aeronautics and Space Administration (NASA), 30, 305, 337–38
US National Academy of Sciences, 321
vaccines, sleep loss and response to, 182–83
Van Cauter, Eve, 172–75
violence, and sleep deprivation, 148
Wagner, Ullrich, 228–28
wakefulness
adenosine levels and, 32
adolescent circadian rhythms and, 93
brainwaves during, 47–48
circadian rhythm control of, 20, 32
evening types (“night owls”) and, 20–22
evolutionary puzzle of, 57
fast frequency brain activity during, 47, 51
melatonin release blockage with daylight and, 24
morning types (“morning larks”) and, 20–22
polyphasic sleep in children with periods of, 85–86
post-prandial alertness dip in, 69
profile of release of, 24
reception of signals during, 53
sleep inertia at beginning of, 143, 223
weight gain
appetite and sleep amount in, 172–73
calorie consumption and sleep amount in, 173–75
food type and sleep amount in, 175–76
hormones affecting, 171–72
sleep deprivation and, 169, 172–78
whales, sleep in, 60–61, 62, 64, 67, 80n
Wilson, Ronald, 311
work schedules
cancer and nighttime shift in, 184, 186
doctors and nurses in hospitals and, 316–22, 335
morning larks versus night owls and, 21–22, 304, 334
organizational change suggestions affecting, 333–38
sleep amount and rhythm and, 265, 279–81
sleep loss and, 297–305
social loafing and, 301–2
World Health Organization (WHO), 3n, 4, 186, 296, 332
worms, sleep in, 57
Xiaoshan, Jiang, 257
“Yesterday” (McCartney), 221
zaleplon (Sonata), 288
zeitgeber, 18